Saw a Time when i was in Grade 6.
OK: On reflection, I think my mistake was to say the twists had to be completed sequentially. Your diagram is more like each of the three subunits has three levers, which can be thrown in any sequence.
No, my bad. That's not right. What I described wouldn't be square, but one triangular half of a square. Ugh. It was so long ago...
Not "very nearly" but exactly like the enzyme situation. I wrote "very nearly" before I decided to account for there being two ways of making the final hop.
I used to draw diagrams like and think about the same probabilities when I was modeling enzyme activation. What you've drawn is very nearly like a three-subunit enzyme, in which each subunit undergoes through three sequential twists to assume the shape it needs to be in before all three subunits do something in unison (or b/c you can get to the end of your route by either of two final hops, the subunits' final act in unison can happen even if one of the subunits had undergone only two out of three twists). The the equivalency of intermediate states (e.g. there are 4 equivalent states of the enzyme in which just one subunit has undergone only two out of the three twists) means there's a lot of entropy in being only partway activated, relative to the amount in being either fully activated or fully inactivated. All else equal, that entropy bonus biases the activation equilibrium toward intermediate inactivation, so there needs to be an energetic payoff to twisting and the final concerted step for the enzyme to be fully activated (say if each twist was brought about by oxygen binding, like in hemoglobin). I had to say because this is one of the few things in the world I supposedly really know about.
You might enjoy this math puzzle tv series about using math to solve (somewhat contrived)everday puzzles. This episode looks at Pascal's Triangle, probability and the Bell Curve. http://youtu.be/uan7tZImcFA
Interestingly, from the clip provided, the elder Ghiz "thundered" about a an ethical philosophy toward economic development only *after* failing to negotiate a better deal with Litton. He was an expert at conveniently embracing popular rhetoric. Fortunately, once his new position took root, I agree, it did *generally* guide subsequent administrations. The current government appears to have no guiding philosophy toward economic development or anything else other than grabbing for whatever comes its way through circumstance. On that basis, its hard to criticize the younger Ghiz's regime as, at least, it is bringing in something, anything. But it is an important, profound and fair response to ask the questions you are implying: Is this kind of industry the right fit for our Island society? Is this what we have become? A branch plant economy for the military-industrial complex? Is this what we want to become? What is the nature of our society and our economy? What is appropriate economic development for our Island society? Who are we? What do we want to be?
hi all,one of Vladimirovich,Vukotin were governors of Raska and Zeta in 12 century, Serbian countries, Rukavina (Vladimirovich) were never croatians to the 20 th century, but Bunjevci, many experts say that bunjevci are Serb Catholics,Today bunjevci in Serbia(Vojvodina) are special minority,in croatia they are not,just croatians.
Thanks Lori re Sept/11,and to Alex Brown Jan/13. followed your advice and today easily got a wonderful,friendly,helpful "Real Person " at Rogers named Tracy who very quickly and kindly helped me.Tracy very politely informed me that monthly " top up reminder" will always pop up even if you have auto top up. This is also to remind those people who may have changed their credit card and did not inform Rogers of change for them to do so. Also thanks to Julia,Nov/12 for the office hrs . Really appreciate all of your info ..THANKS!!!! Hope You ALL Have a Happy Thanksgiving !
Excellent slide deck Peter, esp because of using existing very tangible cases (my fallacy is to often remain too abstract). And I love it that the guy in the blue shirt makes an appearance as well! :)
is a TED talk from Dave Meslin citing lack of clarity and openness in such "public consultations" as to why the public appears apathetic.
Thanks for sharing this!
I just downloaded the episodes from a torrent site!
After searching for years a set of recordings has now been found.
* You'll need uTorrent v. 1.8.3 (no earlier / later version is allowed) * Then create a free membership to TheEmpire.bz * Then login. * Then Browse (search) for "tallship chronicles" * Click on the link to download the torrent file for S01E01 - the first ep. * Then open this into uTorrent and wait. * The file will be downloaded onto your C: drive - probably within a few hours. * Once complete leave it seeding for others to share * Repeat for the other eps.
Yay, congratulations! :-)
A nice interconnectedness story:
Winter River is also a great snowshoeing destination. It lives up to its name in the colder months.
it occurs to me that the curriculum has a glaring hole it it: what we really need is for our children to understand ecosystems in their guts. I’m pretty sure you can’t do this justice when confined to a classroom, no matter how much time you spend on describing “how energy is supplied to, and how it flows through, a food web.”
Woohoo! You've joined the dark side! I have a ukulele friend in Charlottetown if you want to find out where to go to play banjo uke with other people. And if you are ever in Toronto with your banjo uke, come to the Corktown Ukulele Jam -- you might run into me or Dan Misener there (hi Dan!).
If someone didn't know you this story would be a great introduction to the way your mind works
I will need an upgrade soon and I would like to try some of the more open phone options. My geeking skills are limited. If I invested in a Peak phone would the software updates eventually solve the current problems? If it is not consumer ready now when do you expect it would be?
Congrats! Welcome to the club.
I used to work at 20159 88 Avenue Langley, BC V1M 0A4 until 4 months ago. The owners never want to put more hands at the peak hours and hell bent upon saving dollars. I tried my best to stay here but situation worsened day after after. The supervisor-lady treat the employees like slaves and rude and not a civilized lady. She is the reason for so many staff left. What is more irritating is every morning, atleast 2 or 3 dudes from the management come and observe what is going on. Yet they don't want to provide help to the situation. The manager Shivani is nice person but she is limited with no help from the management. I recommend to who so ever want to apply here, reconsider your options. Not a place for to work.
We need to chat more often.